Cathepsin S Inhibitors Neuropathic Pain

Bertil Samuelsson VP Discovery Research Rein Piir CFO / IR
BACE Alzheimer's In-house Cathepsin S Neuropathic pain, In-house rheumatoid arthritis, multiple sclerosis Nucleoside HCV Polymerase Inhibitors. 16 Hepatitis C Polymerase Medivir/J&J program Status • Partnership with Tibotec / Johnson & Johnson since ... Document Retrieval

Noordwijkerhout-Camerino-Cyprus Symposium
Cathepsin S (Cat S) most notably neuropathic pain.2 We originally identified nonpeptidic and noncovalent tetrahydropyrazolopyridine Cat S inhibitors from a virtual screen of the Janssen corporate compound collection.3 As a complementary approach to ... Fetch Content

Virobay
Disorders, neuropathic pain, liver diseases, atherosclerosis, osteoporosis, COPD and cancer. Virobay’s cathepsin inhibitors include compounds that are highly specific for individual cathepsins (e.g., cathepsin S) as well as compounds that are broadly active against multiple cathepsins. ... Access Doc

Contact: Leslie Holsinger, PhD Vice President, Biology 650.833
Of cathepsin protease inhibitors for the treatment of autoimmune diseases, neuropathic pain, liver diseases and cancer, neuropathic pain and liver fibrosis. For more information please visit our website: www.virobayinc.com. Title: style3 ... Get Doc

Combination trial with TMC435 and two new NS5B inhibitors (polymerase inhibitors). The results The cathepsin S project primarily addresses neuropathic pain. ... Doc Viewer

ControlofChronicPainbytheUbiquitin–Proteasome ...
And reverse neuropathic pain established after spinal nerve liga-tion (SNL), chymotrypsin, cathepsin B, papain, or calpain (Mengetal.,1999;KisselevandGoldberg,2001) some inhibitors on chronic pain are mediated through several ... Visit Document

2006 Mid-Atlantic Pharmacology Society Annual Meeting Summary
Inhibitors in the expectation that UNC-13 levels would rise. are analyzing the cathepsin activity in murine cell lysates. Neuropathic pain is a chronic neurological malady for which there are few effective pharmacological interventions. ... Return Document

Présentation PowerPoint
Cathepsin. S . inhibitors. program: of neuropathic pain and rheumatoid arthritis with positive outcomes. Cathepsin S inhibitor: Dengue fever: NS3 proteaseinhibitor. Target: Dengue virus NS3 protease,essential for viral replication. Medical. need. ... Retrieve Document

BACE Alzheimer's In-house Cathepsin S Neuropathic pain, In-house rheumatoid arthritis, multiple sclerosis COPD PI COPD In-house World exc. China consisted of SEK 12.3 m for research collaboration funding on HIV protease inhibitors, SEK 7.6 m ... Retrieve Document

GlaxoSmithKline - Product Development Pipeline
Relacatib† cathepsin K inhibitor osteoporosis & osteoarthritis (also bone metastases) I 681323 p38 kinase inhibitor neuropathic pain (also atherosclerosis, COPD & rheumatoid II arthritis) 683699† dual alpha4 integrin antagonist (VLA4) multiple sclerosis II ... Read Full Source

/MED/30/314/2010 Structure-guided design of novel non-peptidicnoncovalent selective inhibitors of the spinal microglial cathepsin s for the treatement of neuropathic pain synthase kinase-3β inhibitors for neurogenesis For Relieving Postoperative Pain In ... Visit Document

SEB Enskilda November 12 2009
BACE Alzheimer's In-house Cathepsin S Neuropathic pain, In-house rheumatoid arthritis, multiple sclerosis BACE Inhibitors Alzheimer’s disease. 19 BACE-1 Inhibitors in development BI Novartis Medivir Pre-clin Ph I BMS Schering ElanPharm? Wyeth Merck GSK Janssen ... Fetch Document

Management Of Treatment-emergent Peripheral Neuropathy In ...
Proteasome inhibitors inhibit the 26S proteasome, either rever-sibly (bortezomib, MLN9708,7 CEP-18770 Cathepsin G activity was reduced and neurite growth neuropathic pain treated at the Dana--Farber Cancer Institute ... Fetch Doc

Opening Ceremony And Reception Banquet
Structure Based Design and Synthesis of Noncovalent Inhibitors of Cathepsin S and Their Applications in Treating Neuropathic Pain 10:00-10:30 Inivted Lecture 44 Weizheng (William) Xu (MGI Pharmaceutical, USA) ... Read Document

Painful Osseous Metastases - :::::Pain Physician:::::
Reported to be useful for the treatment of neuropathic cancer pain (123), and as a synergistic adjuvant to opi-oid analgesics. Caraceni and colleagues (124) published . all Cathepsin K inhibitors, except for odanacatib, have been suspended (241). ... Fetch Document

Medicine, KhonKaen University R. Nanagara
Joint pain, stiffness and limitation of movement… with mild to moderate synovitis Cathepsin (lysosomal protease) MMP (stromelysin,collagenase, gelatinasse, ADAMP) Aggrecanase (s) metabolic neuropathic congenital endocrine acute repetitive overused ... Fetch Doc

Amura And Grünenthal Enter Research Collaboration In Pain ...
Collaborate on the development of ‘cathepsin inhibitors’ to treat pain and inflammation. Starting from are implicated in a wide a range of commercially attractive therapeutic indications such as neuropathic pain, arthritis, osteoporosis, ... Access Document

T H E A L Z E T O S M O T I C P U M P N E W S L E T T E R ...
Neuropathic pain, stroke & ischemia, neurodegeneration, observed in studies in which cathepsin B, and either MMP-9 or uPAR, enzyme inhibitors, antidepressants, anticonvulsants, dopaminergics, opioids, neuropeptides, ... Content Retrieval

The Biochemical Origin Of pain: The Origin Of All pain Is ...
Nociceptive or neuropathic pain, the underlying origin is inflammation and the inflammatory response. cathepsin, and serine proteases, such as tissue plasminogen activator. Under normal circumstances, and their inhibitors, such as TIMP. As part of the cartilage degradation and syn- ... Retrieve Document

Nociception - Wikipedia, The Free Encyclopedia
Pain is also "gated" by signals that descend from the brain to the spinal cord to suppress (and in other cases enhance) incoming nociception (pain) information. Nociception response. When nociceptors are stimulated they transmit signals through sensory neurons in the spinal cord. ... Read Article