Purinoceptors In Microglia And Neuropathic Pain

Open Access New Perspective In Pain Treatment
Neuropathic pain syndrome is a disabling condition which (microglia and astrocytes) [13-16] and nerve growth factor . Purinoceptors are classified into G-protein coupled receptors P2Y and ATP-gated cation channels so-called P2X ... Read Here

NLRD Record April 2012
The role and therapeutic potential of microglia in glioblastoma Determining whether inhibition of D-amino acid oxidase alleviates pain in a rat model of neuropathic pain [2 May 2009] PC1 - (a) and (b), PC2 - (i) Mammary-specific knockout of the Orai1 gene ... Read Document

Number Chairpersons Country Speakers Commission I Locomotion
5 Purinoceptors in microglia-neuron signaling in neuropathic pain Michael Salter Canada 6 NOVEL MECHANISMS OF CENTRAL CHEMOSENSITIVITY Nicholas Dale UK 7 Presynaptic P2X receptors as astrocyte-neuron interface Fusao Kato Japan ... Access Doc

Www.extranet.elsevier.com
Neuropathic pain Spinal cord pain systems Willis Descending Modulation of pain Michael H. purinoceptors - molecular biology, overview ATP as a neurotransmitter P2X receptors Terrance M. Microglia properties Dr. Uwe Karsten Hanisch Microglial response to injury Shinichi ... Return Doc

The Modulation Of Synaptic Transmission By The Glial ...
Spinal microglia in the neuropathic pain state, but until re- ous EPSCs by purinoceptors in the nucleus tractus solitarii of the rat. J Physiol 2001; 530: 469-86. [86] Khakh BS, Gittermann D, Cockayne DA, et al. ATP modulation of ... Doc Retrieval

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Purinoceptors was damaged or dying cells, but it is now recognized that ATP release receptors on spinal microglia in neuropathic pain following the initial discovery by Tsuda and colleagues in 2003 (see [77]). Microglial P2X 4 ... Access This Document

Pharmacologyonline 3: 826-847 (2011) Ewsletter Rossini And ...
P2X 4 and p38-MAPKinase purinoceptors, which intervene in neuropathic Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia. TRENDS Neurosci 2005;28:101-107. 4. Streit WJ. Microglial senescence: does the brain’s immune ... Content Retrieval

Ikeda MOLECULAR PAIN RESEARCH Open Access Contribution Of ...
Neuropathic pain in the juvenile rat Hiroshi Ikeda*, Takaki Kiritoshi and Kazuyuki Murase Abstract Contribution of microglia, purinoceptors and p38 MAPK to hyperexcitability of the spinal dorsal horn by neuropathic pain ... Fetch Doc

INTRATHECAL ADMINISTRATION OF ATP PRODUCES LONG-LASTING ...
Activation of P2-purinoceptors (Jahr and Jessell, 1983; Krishtal et al., 1988). microglia stained with OX-42 showed features of a rest-ing state; oped neuropathic pain even 50 days after peripheral nerve injury ... Access This Document

Abstracts: Connelly M - Dalhousie University - Halifax, Nova ...
*Stinson J, Brown S. Treatment of chronic neuropathic pain with pamidronate: Case report of two adolescents. *Trang T, Beggs S, Salter MW. Purinoceptors in microglia and neuropathic pain. Pflugers Archiv European Journal of Phsyiology, 2006; 452:645-652. *Tremblay I, Sullivan MJL. ... Retrieve Here

NLRD Record April 2012
Neurotransmission in the prostate gland, involvement of P2X1-purinoceptors and a1A-adrenoceptors Using fluorescently tagged stem cells to identify mamamry stem cells Macrophage and microglia expression in relation to the development of acute axonal injury in experimental allergic encephalitis ... Return Document

July 28 Main Hall (1F)
PURINOCEPTORS IN MICROGLIA-NEURON SIGNALING IN NEUROPATHIC PAIN Michael Salter Neurosciences & Mental Health, Hospital for Sick Children, Canada RS IV-15-6 NOVEL MECHANISMS OF CENTRAL CHEMOSENSITIVITY Nicholas Dale Biological Sciences, Warwick University, UK ... View Document

P2 Receptors: P2X Ion Channel Family - Sigma-Aldrich ...
Are there families of P2X and P2Y purinoceptors., Pharmacol. Ther., 64, 445-475 neuropathic pain. P2 Receptors: P2X Ion Channel Family. FOOTNOTES cochlea epithelia, microglia PHYSIOLOGICAL FUNCTION Depolarization, Depolarization, Depolarization, ... Get Doc

Long-term (trophic) Purinergic Signalling: purinoceptors ...
Purinoceptors are extraordinarily widely distributed in all cell types and 44. Inoue K, Tsuda M. Microglia and neuropathic pain. Glia 2009; 57: 1469–1479. 45. Inoue K, Tsuda M, Koizumi S. ATP receptors in pain sensation: involvement of spinal ... Read Content

The P2X Purinergic Receptor: From Physiology To Neurological ...
Inflammatory and neuropathic pain (39) and may play cytes and microglia in persistent pain. Adv. Mol. Cell. Biol. 31, 951–966 58. Milligan, E. D., Maier, S. F., and Watkins, L. R. (2003) purinoceptors). Mol. Pharmacol. 48, 178–183 66. ... Access Full Source

The P2Y Receptor Regulates Microglial Activation By ...
Microglia express several purinoceptors, including a Gi-coupled subtype that has been implicated in ATP- and ADP-mediated migration in vitro. (neuropathic pain), a pathway that may involve nucleotide-evoked release of neurotrophins (BDNF) ... Read Full Source

PHD Thesis
Neuropathic pain all of which adversely affect the quality of a patients‟ daily life. pain states than in the maintenance of pain. This may be due to microglia producing a Purinoceptors are a large family of receptors that include ligand-gated ion ... Read More

Satellite Glial Cell - Wikipedia, The Free Encyclopedia
Particularly the homomultimer P2X3 and the heteromultimer P2X2/3 purinoceptors. has been implicated in the release of interleukin IL-1β from macrophages or microglia and astrocytes. The receptor likely has a part in the cascade of events that end with inflammation and neuropathic pain. ... Read Article